N/V, diarrhea, diaphoresis, blurred vision, insomnia describe which symptom cluster?

N/V, diarrhea, diaphoresis, blurred vision, insomnia describe which symptom cluster?

• A. Acute withdrawal effects
• B. Dopaminergic rebound
• C. Cholinergic rebound
• D. Flu-like symptoms

Answer: (D)

N/V, diarrhea, diaphoresis, blurred vision, and insomnia reflect rebound cholinergic activity after stopping an anticholinergic medication. When muscarinic receptors are no longer blocked, acetylcholine effects surge, increasing GI motility and secretions (nausea, vomiting, diarrhea), triggering sweating, and causing ocular changes like miosis and accommodation-related blurred vision. Insomnia can arise from the CNS arousal and discomfort associated with this rebound. This pattern is specific to cholinergic rebound from withdrawal of anticholinergic therapy, rather than flu-like illness or other withdrawal types, which don’t produce this particular bundle of autonomic and visual symptoms.

N/V, diarrhea, diaphoresis, blurred vision, and insomnia reflect rebound cholinergic activity after stopping an anticholinergic medication. When muscarinic receptors are no longer blocked, acetylcholine effects surge, increasing GI motility and secretions (nausea, vomiting, diarrhea), triggering sweating, and causing ocular changes like miosis and accommodation-related blurred vision. Insomnia can arise from the CNS arousal and discomfort associated with this rebound. This pattern is specific to cholinergic rebound from withdrawal of anticholinergic therapy, rather than flu-like illness or other withdrawal types, which don’t produce this particular bundle of autonomic and visual symptoms.